Distinct immune stimulatory effects of anti-human VISTA antibodies are determined by Fc-receptor interaction
VISTA (PD-1H) is an immune regulatory molecule considered part of the next wave of immuno-oncology targets.VISTA is an immunoglobulin (Ig) superfamily cell surface molecule mainly expressed on myeloid cells, and to some extent on NK cells and T cells.In previous preclinical studies, some VISTA-targeting antibodies provided immune inhibitory signals